Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder

Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder

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There is growing evidence that inflammation plays a role in major depressive disorder (MDD).As the main role of regulatory T cells (Tregs) is to control inflammation, this might denote a Treg insufficiency in MDD.However, neither a qualitative nor a quantitative defect of Tregs has been ascertained and no causality direction between inflammation and depression has been established.

Here, after reviewing the moen finney evidence supporting a relation between Treg insufficiency and MDD, we conclude that a novel therapeutic approach based on Treg stimulation could be valuable in at least the subset of patients with inflammatory MDD.Low-dose interleukin-2 appears to be a good candidate as it is not only a safe stimulator of Tregs in humans but also an inhibitor of pro-inflammatory Th17 lymphocytes.Here, we discuss that el reformador tequila anejo a thorough immune investigation as well as immunotherapy will be heuristic for deciphering the pathophysiology of MDD.